While a large percentage of products that companies develop and manufacture are solid, these objects can be some of the trickiest to work with during a scale-up. A scale-up is a common process in chemistry and pharmaceutical production where you take the scale model from the lab and adjust its size so that you can mass-produce the item for commercial sale or common household usage.
However, it’s difficult to do this with solid objects because changes in size may result in changes in density, solubility, or other factors. Here are four tips to identify key experiments for solids scale-up that can help ensure your process is more successful.
1. Define the Proper Parameters
Part of having a successful scale-up for your solid product involves knowing what your final properties should entail. Ideally, you want things to be as close as possible to the scale model, but market trends may want to focus on making it more lightweight or constructing it with a less coarse material.
2. Recognize Solvates and Other Characteristics
One tip to identify the key experiments for your solid scale-up is identifying polymorphs. Many chemical companies utilize modeling programs to see if any of these tough-to-spot characteristics may become unstable or cause problems during the scale-up. If one or more of your solvates or polymorphs are giving you trouble in the program, you may need to explore other chemical opportunities.
3. Checking Reactions to Temperature
A change in temperature can have a drastic impact on solids, liquids, or gases. Understanding how heat flux can affect the isomers of your solid product during scale-up is an important part of the process. Will you need to dry out the particulate solids naturally, or is it safe to use a manual heating method without disrupting the chemical composition too much?
4. Getting Solubility Data
It’s very important to understand how your solid product reacts to water or other liquids. If your solids are supposed to dissolve quickly, does the larger size of the commercial model elongate the process or completely change the settling rates? Experiment with different liquid reactions to see how your chemical product changes its response when exposed to liquids.
Capital Resin Corporation is a reliable developer and manufacturer of chemical compositions in the fields of biochemistry, pharmaceuticals, and more. If you need a reliable aromatic sulfonic acid manufacturer, let us handle the close-up experiments and ensure that your product remains functional and practical throughout the scale-up. For more information on what services we have to offer, don’t hesitate to contact us anytime, and we’ll be happy to assist you.
